Acetylcholinesterase in Thrombocytes

Acid-soluble nucleotides in bovine thrombocytes.

In connection with our studies on bovine aplastic anemia (24), it became important to determine the nature and approximate amounts of the major acid-soluble nucleotides in blood cells. A survey of the literature revealed only meager information on nucleotides in human thrombocytes (5-8) and only one report dealing (6) with another specie. The presence of adenosine diphosphate and adenosine trip...

Thrombocytes and coronary heart disease.

Zebrafish Thrombocytes: Functions and Origins

Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional genomic studies of platelets have been performed but are low throughput and are not cost-effective....

G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes

Collagen activates mammalian platelets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor γ-chain, which has an immunoreceptor tyrosine-based activation motif (ITAM). Cross-linking of GPVI mediates activation through the sequential activation of Src and Syk family kinases and activation of PLCγ2. Nucleated thrombocytes in fish are activated by collagen but lack an or...

Young thrombocytes initiate the formation of arterial thrombi in zebrafish.

The zebrafish system is an excellent vertebrate genetic model to study hemostasis and thrombosis because saturation mutagenesis screens can identify novel genes that play a role in this vital physiologic pathway. To study hemostatic mutations, it is important to understand the physiology of zebrafish hemostasis and thrombosis. Previously, we identified zebrafish thrombocytes and have shown that...